Latent Folding: Resolution of Levinthal's Paradox via Grade Decomposition
Levinthal's paradox observes that the conformational space of a protein with $N$ residues has dimension $d \approx 2N$ (dihedral angles), yielding $\sim 3^{2N}$ possible conformations—a brute-force search time exceeding the age of the universe for typical proteins. Yet proteins fold reliably in milliseconds to seconds.
Verified
33 claims
2,796 words